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KMID : 0363320180390040676
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Journal of Korean Oriental Internal Medicine
2018 Volume.39 No. 4 p.676 ~ p.685
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Single Dose Oral Toxicity Test of Peucedani Radix in ICR Mice
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Kwon Da-Hye
Kim Min-Young
Hwangbo Hyun
Ji Seon-Yeong
Park Cheol
Choi Yung-Hyun
Hong Su-Hyun
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Abstract
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Objectives: The aim of this study was to estimate the single oral toxicity of Peucedani Radix (PR) ethanol extracts. PR is one of the important herbs for removal of phlegm, the viscous turbid pathological product that can accumulate in the body and cause a variety of diseases. However, research on the pharmacologic toxicity of PR is lacking.
Methods: In this study, PR was orally administered to 5-week-old male ICR mice at an oral dose of 2,000, 3,000, or 5,000 mg/kg. After a single-dose administration, the mortality and behavioral changes were observed daily and body weights were measured every two days. After 14 days, the organ weight, organ index, macroscopy, hematological analysis, and serum biochemistry analysis were determined.
Results: No mortality, body weight changes, abnormal behavioral changes, or anatomical signs of toxicity were found. The organ weight, organ index, hematological analysis, and serum biochemistry analysis were also within the normal ranges.
Conclusions: These results suggest that the 50% lethal dose of PR is more than 5,000 mg/kg. This could indicate that PR is a safe drug without acute toxicity and side effects.
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KEYWORD
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50% lethal dose, ICR mouse, Peucedani Radix, single dose toxicity test
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